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Perimenopause care for women 35+
The anxiety, the 3am waking, the brain fog your doctor called stress. What feels like the edge of a cliff is actually the beginning of clarity. There is a hormonal explanation, and a real treatment that works.
What we treat
Perimenopause does not affect just one part of you. It shows up in your sleep, your mood, your energy, your weight, and your sense of self. Every treatment plan starts with a free consultation. No payment until after your clinician has assessed your case.
Why sela
There is no supplement proven to treat hot flashes. No wellness retreat that reverses hormonal decline. Sela prescribes what the clinical evidence actually supports — bioidentical hormone therapy, compounded to your exact dosage, reviewed by a specialist who chose to focus on this.
How it works
What actually works
Hundreds of products launched in the last four years claiming to treat menopause symptoms. Here is what the clinical evidence actually says.
Patient stories
I was 37, seeing a therapist for anxiety, and taking SSRIs that were not working. A Sela clinician said this is estrogen, not serotonin. Three weeks later I felt like myself for the first time in two years.
Rachel M. — age 37, Chicago
My GP told me I was too young at 40 and suggested I try meditating. Sela had a treatment plan to me before my next GP appointment would have even been scheduled.
Diane K. — age 40, Austin
I had been waking at 3am every night for almost two years. Progesterone fixed it in eleven days. I wish someone had told me about this years ago.
Priya S. — age 43, New York
Free clinician review. Choose a plan only after you have the full picture.
No credit card required. Results in under 24 hours.
How it works
No waiting rooms, no dismissive appointments.
The clinician review is free. You only pay if treatment is right for you.
Symptoms
These are not signs of aging, stress, or anxiety. They are hormonal — and they can start a full decade before most women expect them to.
If you are experiencing three or more of these consistently, a conversation with a clinician who specializes in hormonal health is worth it.
Pricing
A specialist clinician reviews your case at no charge. You choose a plan only after you have the full picture.
Medication billed separately — typically $35 to $90/moOur clinicians
Every clinician on Sela has specific training in women's hormonal health. They chose this specialty. That matters.
The Sela Journal
Evidence-based writing on perimenopause, hormonal health, and feeling like yourself again.
Treatment
The most evidence-based treatment for perimenopause symptoms. Not a supplement. Not a wellness protocol. A clinically prescribed intervention that addresses the root cause.
Perimenopause is a hormonal transition, not a single event. Estrogen, progesterone, and testosterone begin declining — not steadily, but erratically. It is the fluctuation, not just the decline, that drives most symptoms.
Hormone therapy works by replenishing what is declining. Bioidentical HRT uses hormones structurally identical to those your body produces — not synthetic alternatives with different molecular shapes.
The Women's Health Initiative trial published results in 2002 suggesting HRT increased the risk of breast cancer, heart attack, and stroke. Prescriptions collapsed overnight. For two decades, women suffered symptoms that had treatments.
Current guidelines from NAMS and the Endocrine Society support HRT as safe and appropriate for most women under 60 who begin treatment within ten years of their last period.
Bioidentical hormones are molecularly identical to those your body produces. Transdermal delivery bypasses the liver, which significantly reduces the risk profile compared to oral synthetic hormones.
Every Sela prescription is compounded to your exact dosage by a licensed 503A pharmacy.
A Sela clinician reviews your intake and gives you an honest assessment. Free. No obligation.
Treatment
Hormonal sleep disruption is one of the most undertreated perimenopause symptoms. The 3am waking has a name, a cause, and a treatment.
Progesterone has a direct sedative effect on the brain via GABA receptors. As it declines in perimenopause, sleep architecture changes. You fall asleep fine but wake in the early hours and cannot get back to sleep. This is not insomnia in the traditional sense. It is a progesterone signal.
Estrogen decline drives a separate but related problem — night sweats that wake you drenched. Both have clinical solutions.
Oral micronised progesterone taken at bedtime is the primary treatment for hormonal sleep disruption. Most patients notice improvement within 7 to 14 days.
For women also experiencing night sweats, estradiol is added to the protocol.
Free clinician review. No obligation. Results within 24 hours.
Treatment
Estrogen is a direct regulator of serotonin, dopamine, and GABA. The anxiety that appeared in your late 30s is not a mental health crisis. It is a hormonal one.
Estrogen modulates serotonin receptors directly. SSRIs treat the serotonin pathway but do not address the hormonal fluctuation driving the problem.
Hormone therapy stabilises the underlying hormonal environment. For many women, this resolves mood symptoms more effectively than antidepressants.
Estrogen is neuroprotective. As it fluctuates in perimenopause, women report difficulty finding words, slower recall, and cognitive blunting that is often dismissed as stress or aging.
Free clinician review. No obligation.
Treatment
The abdominal weight gain that appears in perimenopause is not a lifestyle failure. Estrogen directly regulates insulin sensitivity, fat distribution, and metabolic rate.
Estrogen regulates adipokines and insulin sensitivity. When it declines, fat redistributes from the hips and thighs to the abdomen. The same diet and exercise habits that worked at 32 stop working at 42 for this reason alone.
Hormone therapy restores estrogen's metabolic role. For women where weight gain is significant, GLP-1 medication may also be appropriate.
GLP-1 receptor agonists improve insulin sensitivity and reduce appetite — both of which are impaired by hormonal shifts. When combined with HRT, the combination addresses the hormonal root cause and the metabolic consequence simultaneously.
Free clinician review. No obligation.
Treatment
Changes in libido and sexual comfort in your 30s and 40s are almost entirely hormonal. Both are common, both are treatable, and neither requires accepting them as inevitable.
Low libido is driven primarily by declining testosterone. As it declines in perimenopause, libido often drops significantly. Low-dose therapy restores it.
Vaginal dryness and discomfort are driven by declining estrogen. Local vaginal estrogen therapy is highly effective and is considered safe for most women.
Only 17% of women who experience these symptoms ever raise them with a doctor. The barrier is not medical — it is conversational. Sela removes that barrier.
Free clinician review. No obligation.
Treatment
Estrogen plays a direct role in collagen production, skin hydration, and hair follicle health. These changes are hormonal in origin and respond well to treatment.
Estrogen stimulates collagen synthesis and maintains skin thickness, elasticity, and moisture. Skin loses approximately 30% of its collagen in the first 5 years after estrogen begins to decline. Hormone therapy significantly slows this process.
Hair thinning follows a similar hormonal logic. Hormone therapy, topical minoxidil, and finasteride all have supporting evidence.
Androgenic alopecia in women presents as diffuse thinning across the crown and is frequently dismissed as normal. It is not normal. It is hormonal and it responds to treatment.
Topical minoxidil prolongs the growth phase of the hair cycle. Finasteride reduces the conversion of testosterone to DHT. Both are most effective when started early.
Free clinician review. No obligation.
Treatments
Every Sela treatment is compounded to your exact dosage by a licensed 503A pharmacy. Free shipping on every order. Pause or cancel anytime.
Our mission
The average woman spends seven years experiencing perimenopause symptoms before receiving a correct diagnosis. In that time she is told she is stressed, anxious, depressed, or simply getting older. She is prescribed antidepressants when her estrogen is dropping. She is told she is too young. She is sent home.
Sela was built to close that gap. A free clinician assessment. Evidence-based treatment. Prescriptions compounded to your exact dosage, shipped to your door.
We named the company Sela — the Hebrew word for cliff. Because what feels like the edge is usually the beginning.
Clinical philosophy
The problem we are solving
Free clinician review. No credit card. Results in under 24 hours.
FAQ
Straight answers. No hedging.
Our team is happy to help before you commit to anything.
Join us
Sela is a small, focused team working on one of the most underfunded and underserved areas in medicine. We are looking for people who find that motivating.
How we work
Every decision traces back to what the data actually says. We do not build features to look innovative. We build what helps.
If you build something at Sela, it ships. If you spot a problem, you fix it. Everyone here has real scope.
We are helping women get diagnoses they were denied. That context shapes how everyone on the team approaches their work.
Open roles
We hire ahead of the curve. If you think you belong here, send us a note.
Legal
We collect information you provide directly to us when you complete the symptom assessment, book a consultation, or create an account.
We use your information to provide our services, connect you with licensed clinicians, process your prescriptions, and communicate with you about your care. We do not sell your personal information.
Sela Health is committed to protecting the privacy of your health information in compliance with the Health Insurance Portability and Accountability Act.
Questions? Contact us at privacy@selahealth.org.
Legal
By accessing or using Sela Health, you agree to be bound by these terms of service.
Sela Health provides telehealth services facilitated by licensed healthcare providers. The information and services provided are not a substitute for professional medical advice, diagnosis, or treatment.
Subscription fees are billed monthly in advance. You may cancel at any time. Medication costs are billed separately.
Questions? Contact us at hello@selahealth.org.